Yancy investigates when several shopkeepers along Duquense Street pay twice as much for what their property is worth, & are subsequently robbed & murdered. He learns that a projected railroad spur is to be built to the waterfront through that shopping district and unscrupulous Northerners plan to use illegal means to grab all the available real estate before the project is officially announced.
Derringer is falsely accused of complicity in a waterfront property theft. Administer Colton manages to get Matthew Younger to drop the charges, but Yancy discovers the accuser may be throwing charges around to conceal the real perpetrators. His investigations lead him to a waterfront dive and its grave-robbing habitués.
Young Charles Ward has disappeared while traveling in Kansas leading detectives Matt and Margaret to discover why. The local sheriff reports others missing.
Union soldier Maj. Towns (Rhodes Reason) asks fur trapper and Indian scout Luther "Yellowstone" Kelly (Clint Walker) to scout for the Army in Sioux territory. Kelly ventures into the area, only to be taken prisoner by the Sioux. Since Kelly saved the life of Chief Gall (John Russell) years before, the chief promises to free him if Kelly treats wounded Arapaho maiden Wahleeah (Andra Martin). Soon Kelly and the recovered Wahleeah are caught between Towns' soldiers and the vengeful Sioux.