Things do not run smoothly when Amy moves in with Sheldon, and Leonard and Penny have to intervene; Howard and Bernadette find unexpected guests at their house when they decide to cancel their vacation plans.
Penny learns there are fans of her performance in "Serial Ape-ist" when she and Leonard attend a Comic Con event; Amy hosts a brunch at Penny's apartment; Wolowitz makes an impulsive purchase.
A tight-knit group of friends living in Manhattan -- three girls and three guys -- navigate the complexities of adulthood and rely on the companionship, comfort and support they get from each other to deal with the pressures of life.