While Express Agent Jeff Milton is guarding a payroll safe on a train, he is shot by a gang of bandits, and his left arm is nearly shattered; a Tucson surgeon races against the clock to save Milton's life and to save his arm from amputation.
Deputy James Masterson and a group of lawmen from Ingalls, Kansas, attempt to seize the official county seal from the nearby town of Cimarron; their raid turns deadly when a mob of angry townspeople opens fire to defend the Cimarron courthouse.
After Anne Bailey's husband is killed by Native Americans, she defies the social norms of the frontier and becomes a horseback courier, risking her life to race through hostile territory delivering vital supplies to isolated forts and settlements.
The cowboys process hundreds of new cattle as part of their deal with a local rancher; Bubba and Kaley call in favors to get a new barn built; Booger and Jaclyn worry she may lose her job; Cody decides to write a book about cowboy values.
In advance of a presidential visit to the small town of Suddenly, California, a trio of FBI agents enters the Benson family's home to assess potential security risks. Once inside, leader John Baron (Frank Sinatra) reveals himself as a psychopathic assassin, and he kidnaps the family in order to use their house as his vantage point in his plot to kill the president. Sheriff Tod Shaw (Sterling Hayden) matches wits with the assassin and his gang in an attempt to save the day.
Soon after ranch hand Frank Hamer joins the Texas Rangers, he helps them hunt down a mysterious killer, takes part in his first gunfight, and demonstrates a natural gift for detective work that launches a legendary career in law enforcement.
After frontier physician Doctor Susan Anderson accepts a marriage proposal, she finds herself juggling wedding arrangements and a life-or-death medical case; as her wedding day approaches, Doc Susie is forced to choose between love and medicine.
When Chief Pontiac organizes a coalition of Native American tribes to attack British forts, frontier trader George Croghan risks his life on a perilous journey into the wilderness to find Pontiac, negotiate a peace agreement and prevent war.
Outlaw John Henry Lee (Willie Nelson) and his gang are bank robbers tearing through Texas. When their next heist is on a train, Lee's freedom comes to an end when Capt. Owen Hayes (Richard Widmark) of the Texas Rangers catches the thief red-handed. Released after 20 years, Lee wastes no time picking up where he left off -- which pushes Hayes to come out of retirement to catch his man again. But Hayes is not the only one after Lee when a young bandit (Shaun Cassidy) targets the old crook.