Perry hopes his mother, Margaret, can get a grip on the hoarding habits destroying their home; Laura wants to stop collecting before she endangers her kids and loses her husband.
Boys Giovanni and Owen share the rare condition Schwartz-Jampel Syndrome, which permanently and painfully contracts their muscles; the two share hardships and triumphs, and strike up a friendship.
A woman gets a Christmas tree imbedded in her neck; a boy out fishing almost chokes on a barb; a man is filled with enough air to fill 1000 balloons; learn how they survived.
A man gets a wire embedded in his heart; three-year-old swallows magnets; woman has a pencil in her brain; man has a five-centimeter splinter removed from his eye.
A car accident leaves a pole penetrating a man's mouth and neck, a man accidentally eats a sewing needle and a 75-year-old man finds out he has had a nail in his face.
Ariel is 23 and has already lost 260 pounds, but finds the excess skin less feminine than being obese; spirited Chantae is desperate to enjoy life again after losing 222 pounds.
Julie's globs of excess skin cause her to recoil from the touch of her children; Andrew shed 300-lbs. by spending every spare moment in the gym, but is now engulfed in empty skin that's killing his dream of body-building.
Megan lost weight after being bullied in high school but is still constantly tormented when she sees her dramatic loose skin in the mirror; Ashley lost 220-lbs. but her excess skin that leaves her in pain.
A woman with an extremely rare skin disorder looks more than twice her age; a baby undergoes risky surgery to cure a mysterious brain condition; three brothers with the same genetic disorder hope for a miracle.