Ashley lost over 200 lbs. in Houston, but a family of enablers threatens her progress; Diana has shed 300 lbs., but knee damage may cause her to regain weight.
Ashley hits an emotional wall and is desperate for skin surgery, but she's not losing any weight; after being evicted, Nicole is forced to move back to Ohio, which could impact her weight loss journey.
A young child blisters after exposure to a few minutes of sun; Doctors make a discovery that the child's inability to sweat is one symptom of a mysterious disorder.
After a young man blows his nose, he becomes violently ill and passes out; his condition progressively worsens while doctors try to diagnose what's wrong before one more sneeze kills him.
Decades after a car accident, a woman loses the ability to speak; when her speech returns, she speaks with a foreign accent; one doctor thinks he knows why.
A woman believes her neighbors want to kill her; a man is near death after an arrow pierces his chest; two women with swollen abdomens refuse to explain the cause of their pain.
A circus sword-swallower suffers from a persistent case of hiccups; a mother and daughter mysteriously collapse in the ER; a woman loses control of her legs at her daughter's graduation.
An ER doctor's friend arrives at the hospital combative and out of control; a cyclist's throat is torn open when a driver opens a car door in her path; a nursing student is found passed out on the hospital floor.
A young girl is mysteriously paralyzed from the waist down; a young man complains of a splitting headache; a bride-to-be has appendicitis on her wedding day.
Niki's softball career is cut short by her obesity; she wants to relive her dreams by coaching her son, but her food addiction threatens her ability to live her dreams and get bariatric surgery.
Keith's big size is on the verge of ruining his marriage and his health; he must fight the temptations of a cruise vacation in order to make weight for life-saving bariatric surgery.
Crystal has been hiding her sexuality from her family and close friends for years; that secret has fueled an eating addiction, and Crystal needs bariatric surgery to save her life.
With her weight spiraling, Stephanie needs her mom's help to care for her three kids; she's at the point where she'll have to lose weight or risk not having the chance to see her kids grow up.